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. 2017 Sep 25;22(1):409–416. doi: 10.1111/jcmm.13329

Figure 5.

Figure 5

Effects of Rb1 on macrophage polarization in atherosclerotic lesions of ApoE−/− mice. (A, B) Representative images of MOMA‐2+ iNOS + and MOMA‐2+Arg‐I+ macrophages in situ in corresponding groups (NC: control group; Rb1: Rb1 treatment group). (C, D) Statistics of the number of MOMA‐2+ iNOS + and MOMA‐2+Arg‐I+ macrophages in atherosclerotic lesions in control and Rb1‐treated ApoE−/− mice. Scale bar: 20 μm. *P < 0.05; n = 6. (E) Representative immunoblots of iNOS (M1 marker) and Arg‐I (M2 marker) in vivo. (F) Statistics of iNOS and Arg‐I expression relative to the β‐actin level. Data are presented as means ± S.D.; *P < 0.05, compared to control group; n = 3.