Table 2.
Function of FGFs to cells of CNS
| Members of FGF family | Mesenchymal stromal cell | Oligodendrocytes | Neurons | Astrocyte |
|---|---|---|---|---|
| FGF1 | Inhibit it product CSPG | |||
| FGF2 | Induce it to Schwann cell phenotype 80 | Dedifferentiation of mature oligodendrocytes to an immature state 32, 76, 79 | Enhance the survival and outgrowth of neuronal cell 31, 32, 33 |
Active astrocytes in a small dosage 92, 93, 94, 95
High concentrations of bFGF inhibit activation of astrocytes 98 |
| FGF8 | Protect cerebellar neurons 40, 41 | |||
| FGF9 | A survival factor for many neurons 42, 43 | |||
| FGF13 | Induce neuronal polarization 44 | |||
| FGF20 | Protection dopaminergic neurons 46 |