Table 1.
Dysregulated Hippo pathway components in human tumours
| Hippo pathway component | Cancer type | Role in human tumours | Reference |
|---|---|---|---|
| MST1/2 | Gastric cancer | Invasion, metastasis, higher clinical stage, and poorer prognosis | 10, 79, 80, 81, 82, 83, 84, 85, 133 |
| Colorectal cancer | |||
| Hepatocellular cancer | |||
| Breast cancer | |||
| Gastric cancer | |||
| LATS1/2 | Prostate cancer | Proliferation, metastasis, increased clinical stage, reduced overall survival, and recurrence‐free survival | 79, 80, 82, 84, 130, 133 |
| Renal cancer | |||
| Non‐small lung cancer | |||
| Colorectal cancer | |||
| Gastric cancer | |||
| Bladder cancer | |||
| Mask1/2 | Prostate cancer | Proliferation, migration | 86, 87, 88, 89 |
| Myeloma | |||
| Leukaemia | |||
| Bladder cancer | |||
| YAP1 | Bladder cancer | Proliferation, invasion, metastasis, higher clinical stage, reduced overall survival, metastasis‐free survival, and chemotherapy resistance | 12, 14, 15, 89, 134, 136 |
| Gastric cancer | 8, 84, 124, 132 | ||
| Colorectal cancer | 75, 82, 125, 126 | ||
| Squamous cell carcinoma | 116 | ||
| Non‐small cell lung cancer | 9, 92, 119 | ||
| Ovarian cancer | 11, 85 | ||
| Uveal melanoma | 93 | ||
| Endometrial cancer | 94 | ||
| Hepatocellular cancer | 69, 95, 107, 109, 110 | ||
| Pancreatic ductal adenocarcinoma | 68, 96 | ||
| Cholangiocarcinoma | 91 | ||
| Head and neck cancer | 90 | ||
| Breast cancer | 58, 115 | ||
| Malignant mesothelioma | 70 | ||
| Prostate cancer | 86 | ||
| Endometrial cancer | 94 | ||
| Medulloblastomas | 114 | ||
| Meningiomas | 139 | ||
| TAZ | Hepatocellular cancer | Proliferation, invasion, metastasis, higher clinical stage, shorter overall survival, disease recurrence, poor prognosis and chemotherapy resistance | 97, 107 |
| Retinoblastoma | 102 | ||
| Gastric cancer | 84, 123 | ||
| Colon cancer | 82, 101 | ||
| Oral cancer | 98 | ||
| Ovarian cancer | 104 | ||
| Endometrial cancer | 94, 103 | ||
| Osteosarcoma | 105 | ||
| Non‐small cell lung cancer | 100, 117, 119 | ||
| Breast cancer | 40, 58, 111, 138 | ||
| Tongue squamous cell carcinoma | 99 | ||
| lioma | 106 | ||
| Bladder cancer | 136 |