Table 2.

Summary of clinical correlations between dysregulated Hippo pathway components and bladder cancer

Hippo pathway component	Role in bladder cancer development	References
MST1/2	MST1/2 and RUNX3 collaborate and mediate BC cell death	132, 133, 134
RUNX3	Complicated interaction among MST1/2, RUNX3 and SAV1 deregulate the YAP‐TEAD activity and is crucial in BC cell proliferation and apoptosis
LATS1	Remarkably low level in BC tissues	131
	Alterations of single base pairs in this gene are observed
Mask2	Mask 2 is required for YAP‐induced BC cell growth and migration	89
YAP1	Elevated YAP1 expression significantly associates with poor clinicopathologic stage and adverse patient survival	14, 15
	Further, YAP1 expression is inversely correlated with chemotherapy sensitivity	142
TAZ	TAZ together with YAP1 protect KLF5 from degradation in BC	137
	Knockdown of KLF5 induces BC cell apoptosis