• Introduction

• The Hippo pathway

‐ Overview of the Hippo signalling pathway

‐ The network of upstream signals of the Hippo pathway

‐ Regulation of YAP1 and TAZ

Extrinsic regulators

Cell contact and morphology

Extrinsic stress signals

G protein‐coupled receptors (GPCRs)

Intrinsic regulators

E proteins

Cell cycle

Other signalling pathways

• The Hippo pathway and its role in cancers

‐ Clinical correlation between the upstream Hippo pathway and human cancers

‐ YAP1/TAZ are key co‐effectors of the Hippo pathway in human cancers

• Deregulation of the Hippo pathway and its role in bladder cancer

‐ The Hippo pathway in urinary tract development

‐ The role of the Hippo signalling pathway in bladder cancer

• Conclusions

• Future perspectives

• Acknowledgements

• Conflict of interests