Table 2.
The 20 differentially expressed proteins in serum identified by LC‐MS/MS analysis in CS and normal control samples
| Accession number | Protein name | CS mean | CS S.D. | Control mean | Control S.D. | Ratio (CS/control) | Up‐ or down‐regulation | −Log P‐value | q value | Differentially expressed proteins |
|---|---|---|---|---|---|---|---|---|---|---|
| CO9_HUMAN | Complement component C9 OS = Homo sapiens GN = C9 PE = 1 SV = 2 | 17.432 | 0.220 | 16.912 | 0.165 | 1.434 | UP | 4.463 | 0.000 | + |
| TAGL2_HUMAN | Transgelin‐2 OS = Homo sapiens GN = TAGLN2 PE = 1 SV = 3 | 15.599 | 0.287 | 14.964 | 0.233 | 1.552 | UP | 4.014 | 0.000 | + |
| CRP_HUMAN | C‐reactive protein OS = Homo sapiens GN = CRP PE = 1 SV = 1 | 16.620 | 0.801 | 15.297 | 0.210 | 2.502 | UP | 3.702 | 0.002 | + |
| LBP_HUMAN | Lipopolysaccharide‐binding protein OS = Homo sapiens GN = LBP PE = 1 SV = 3 | 16.160 | 0.407 | 15.331 | 0.343 | 1.776 | UP | 3.593 | 0.003 | + |
| SHBG_HUMAN | Sex hormone‐binding globulin OS = Homo sapiens GN = SHBG PE = 1 SV = 2 | 16.518 | 0.254 | 17.181 | 0.335 | 0.631 | Down | 3.643 | 0.003 | + |
| VWF_HUMAN | Von Willebrand factor OS = Homo sapiens GN = VWF PE = 1 SV = 4 | 16.863 | 0.303 | 16.356 | 0.178 | 1.422 | UP | 3.293 | 0.003 | + |
| MMP9_HUMAN | Matrix metalloproteinase‐9 OS = Homo sapiens GN = MMP9 PE = 1 SV = 3 | 15.666 | 0.313 | 15.151 | 0.216 | 1.428 | UP | 3.041 | 0.005 | + |
| A1AG1_HUMAN | α‐1‐acid glycoprotein 1 OS = Homo sapiens GN = ORM1 PE = 1 SV = 1 | 17.388 | 0.269 | 16.872 | 0.289 | 1.430 | UP | 2.914 | 0.008 | + |
| SAA2_HUMAN | Serum amyloid A‐2 protein OS = Homo sapiens GN = SAA2 PE = 1 SV = 1 | 17.382 | 0.453 | 16.777 | 0.169 | 1.522 | UP | 2.766 | 0.010 | + |
| K1C10_HUMAN | Keratin, type I cytoskeletal 10 OS = Homo sapiens GN = KRT10 PE = 1 SV = 6 | 16.266 | 0.080 | 16.844 | 0.507 | 0.669 | Down | 2.422 | 0.016 | + |
| A2GL_HUMAN | Leucine‐rich α‐2‐glycoprotein OS = Homo sapiens GN = LRG1 PE = 1 SV = 2 | 16.537 | 0.528 | 15.868 | 0.266 | 1.590 | UP | 2.430 | 0.017 | + |
| CO4A_HUMAN | Complement C4‐A OS = Homo sapiens GN = C4A PE = 1 SV = 2 | 17.520 | 0.278 | 16.919 | 0.468 | 1.517 | UP | 2.357 | 0.018 | + |
| K2C1_HUMAN | Keratin, type II cytoskeletal 1 OS = Homo sapiens GN = KRT1 PE = 1 SV = 6 | 16.021 | 0.171 | 16.823 | 0.721 | 0.573 | Down | 2.296 | 0.020 | + |
| HBG2_HUMAN | Haemoglobin subunit γ‐2 OS = Homo sapiens GN = HBG2 PE = 1 SV = 2 | 15.672 | 0.503 | 16.409 | 0.482 | 0.600 | Down | 2.228 | 0.023 | + |
| KCRM_HUMAN | Creatine kinase M‐type OS = Homo sapiens GN = CKM PE = 1 SV = 2 | 15.127 | 0.469 | 14.556 | 0.279 | 1.486 | UP | 2.198 | 0.024 | + |
| APOC1_HUMAN | Apolipoprotein C‐I OS = Homo sapiens GN = APOC1 PE = 1 SV = 1 | 17.607 | 0.543 | 18.237 | 0.319 | 0.646 | Down | 2.074 | 0.029 | + |
| K22E_HUMAN | Keratin, type II cytoskeletal 2 epidermal OS = Homo sapiens GN = KRT2 PE = 1 SV = 2 | 14.629 | 0.233 | 15.213 | 0.540 | 0.667 | Down | 2.055 | 0.030 | + |
| SAA1_HUMAN | Serum amyloid A‐1 protein OS = Homo sapiens GN = SAA1 PE = 1 SV = 1 | 16.743 | 0.756 | 15.982 | 0.225 | 1.695 | UP | 1.977 | 0.032 | + |
| IGHG1_HUMAN | Ig γ‐1 chain C region OS = Homo sapiens GN = IGHG1 PE = 1 SV = 1 | 16.583 | 0.548 | 17.162 | 0.350 | 0.669 | Down | 1.777 | 0.045 | + |
| A1AT_HUMAN | α‐1‐anti‐trypsin OS = Homo sapiens GN = SERPINA1 PE = 1 SV = 3 | 17.018 | 0.559 | 16.487 | 0.235 | 1.445 | UP | 1.737 | 0.048 | + |
The spectral intensity was log‐transformed and compared by Student's t‐test with permutation‐based FDR test using Perseus. The significance cut‐off of q values was 0.05, and ratio cut‐off values were 1.42 or 0.70. Differentially expressed proteins were assigned if ratio ≥1.42 or ≤0.70 and q values < 0.05.