Figure 2.

Autophagic switch from a cytoprotective to a cytotoxic function. Cytoprotective autophagy prevents the cancer cell death and is induced by some particular conditions in various cancer models. All the conditions leading to cytoprotective autophagy are colored in red. When an autophagic switch occurs, cytoprotective autophagy turns into cytotoxic autophagy, and helps to kill the cancer cells. All the conditions leading to the induction of cytotoxic autophagy are colored in green.

Cancer model	Condition 1	Condition 2	Reference
Breast cancer	Radiotherapy	Radiotherapy + vitamin B3	[62,63]
Breast cancer	Gemcitabine	Gemcitabine + Estrogen receptor signaling	[65]
Non Small Cell Lung cancer	Low inhibition of EGFR signaling	High inhibition of EGFR signaling	[66,67]
Colon cancer	Topotecan	Topotecan + mutated p53 status	[70]
Breast cancer Neuroblastoma Multiple myeloma	Beclin 1/Bcl-2 complex	Disruption of Beclin 1/Bcl-2 complex	[74] [75] [76]
Breast cancer Colon cancer	Sphingosine 1 phosphate signaling	Ceramide signaling	[79] [80]
Acute myeloid leukemia	Strong mTOR inhibition	Low mTOR inhibition	[81]