Table 2.
Micro-RNAs (miRNAs) involved in EMT in colorectal cancer.
| Factors | Upstream Regulators | Target Genes | Refs |
|---|---|---|---|
| miRNAs involved in inhibiting EMT | |||
| miR-200 family | P53/ZEB1/SIX1 | ZEB1, ZEB2 | [125,126] |
| miR-429 | P53/ZEB1/SIX1 | HOXA5 | [159] |
| miR-34a | SNAIL, ZEB1, IL-6/STAT3 | SLUG, ZEB1, IL-6R | [134,135] |
| miR-9 | N/A | E-Cadherin | [58] |
| miR-21 | AP-1/ETS1 | ITGβ4 | [150] |
| miR-138 | N/A | TWIST2 | [137] |
| miR-132 | N/A | ZEB2 | [131] |
| miR-30b | N/A | SIX1 | [139] |
| miR-598 | N/A | JAG1/Notch2 | [141] |
| miR-4775 | N/A | TGFβ | [142] |
| miR-363-3p | N/A | SOX4 | [145] |
| miR-375 | N/A | SP1 | [148] |
| miRNAs involved in promoting EMT | |||
| miR-17 | N/A | CYP7B1 | [146] |
| miR-194 | N/A | MMP-2 | [160] |
| miR-675-5p | N/A | DDB2 | [143] |
| miR-150 | WNT/β-catenin | CREB | [161] |
| miR-29a | N/A | KLF4 | [162] |
Abbreviations: SIX1, sineoculis homeobox homolog 1; IL-6R, interleukin 6 receptor; ITGβ4, integrin β4; SOX4, SRY-Box 4; CYP7B1, cytochrome P450 family 7 subfamily B member 1; MMP-2, matrix metallopeptidase 2; DDB2, DNA damage-binding protein 2; CREB, cAMP response element binding; KLF4, kruppel like factor 4.