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Zeta potential of, NP, NP gel, and HPMC hydrogel 0.75% (w/v) upon dilution 1:1 with water or mucin dispersion 2 mg/mL (mean ± SD, n = 3).
| Formulation | Zeta Potential (mV) | |
|---|---|---|
| Solutions | Water | Mucin 2 mg/mL |
| Mucin 2 mg/mL | - | −31 ± 1 |
| Empty NP | +60 ± 4 | +12 ± 0 |
| Empty NP eye drop formulation (HPMC 0.75%) | +36 ± 1 | +7 ± 0 |
| HPMC 0.75% | −14 ± 3 | −9 ± 1 |
