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. 2017 Dec 4;15(12):378. doi: 10.3390/md15120378

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lobocrassin B inhibits the growth of CL1-5 tumor xenografts in nude mice. Nude mice bearing CL1-5 tumors were treated for 28 days. (A) Growth curves of CL1-5 tumor xenografts in Lobocrassin B-treated and untreated mice. Tumor sizes were measured every three days. Data are expressed as the means ± SD (n = 5). * p < 0.05 were the comparisons between vehicle and Lobocrassin B groups (two-way ANOVA). (B) Photograph of tumor tissue (C) and the tumor weight at day 28 were examined. ** p < 0.01 were the comparisons between vehicle and Lobocrassin B groups (student t-test). (D) Body weight of Lobocrassin B-treated and untreated mice (E) Lobocrassin B reduced the cleaved caspase-3 and caspase-8 expression in tumor tissues from lobocrassin B treated mice. The fold of band intensity compared with the vehicle treated mice was marked respectively. All data are representative of at two independent experiments.

Lobocrassin B inhibits the growth of CL1-5 tumor xenografts in nude mice. Nude mice bearing CL1-5 tumors were treated for 28 days. (A) Growth curves of CL1-5 tumor xenografts in Lobocrassin B-treated and untreated mice. Tumor sizes were measured every three days. Data are expressed as the means ± SD (n = 5). * p < 0.05 were the comparisons between vehicle and Lobocrassin B groups (two-way ANOVA). (B) Photograph of tumor tissue (C) and the tumor weight at day 28 were examined. ** p < 0.01 were the comparisons between vehicle and Lobocrassin B groups (student t-test). (D) Body weight of Lobocrassin B-treated and untreated mice (E) Lobocrassin B reduced the cleaved caspase-3 and caspase-8 expression in tumor tissues from lobocrassin B treated mice. The fold of band intensity compared with the vehicle treated mice was marked respectively. All data are representative of at two independent experiments.