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. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Lamtor1 does not have a stably folded structure on its own, but adopts an extended conformation and enwraps the other four subunits around. (a) Structure-based sequence alignment of Lamtor1. Secondary structure elements and residue numbers are indicated above the sequence. Conserved residues of Lamtor1 are shaded in pink. Residues of Lamtor1 interacting with Lamtor2, Lamtor3, Lamtor4 and Lamtor5 are indicated by magenta, cyan, brown and red arrows, respectively. The places that contain loop insertions are marked with orange ovals. (b) Lamtor1 adopts an extended conformation and does not have a hydrophobic core on its own. (c) Interactions among the five subunits of the Ragulator complex. Interactions are represented as double-sided arrows. (d) Interaction interface between Lamtor1 (colored in green) and Lamtor2 (colored in magenta). (e) Interaction interface between Lamtor1 (colored in green) and Lamtor3 (colored in cyan). (f) Interaction interface between Lamtor1 (colored in green) and Lamtor4 (colored in yellow). (g) Interaction interface between Lamtor1 (colored in green) and Lamtor5 (colored in salmon). Hydrogen bonds are indicated as black dashed lines.