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. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The Lamtor4-Lamtor5 subcomplex is stabilized through association with Lamtor1. (a) Structure of the Lamtor4-Lamtor5 subcomplex. (b, c) Main-chain interactions (b) and side-chain interactions (c) between Lamtor4 and Lamtor5. Carbon atoms of Lamtor4 and Lamtor5 are colored in yellow and salmon, respectively. Hydrogen bonds are indicated as black dashed lines. (d) Structure of the Lamtor2-Lamtor3 subcomplex. Note that both Lamtor4 and Lamtor5 lack the α3-helix features present in Lamtor3 and Lamtor2. (e) The α2- and α3-helices of Lamtor1 fill in the gaps on Lamtor4 and Lamtor5, respectively, as compared with the Lamtor2-Lamtor3 complex. Therefore, the Lamtor4-Lamtor5 subcomplex is stabilized.