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. 2017 Dec 20;130(24):2941–2950. doi: 10.4103/0366-6999.220311

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Alternations of Rab7-related PI3KC3 complex components in 12-month-old APP/PS1 mice. (a and b) Western blotting and quantitative analysis of Rab7, UVRAG, and Beclin1 in Wt and APP/PS1 (Tg) cortex. (c and d) Western blotting and quantitative analysis of Rab7, UVRAG, and Beclin1 in Wt and Tg hippocampus. β-actin is used as a loading control (n = 4) *P < 0.05. (e and f) Double immunofluorescence-labeled Beclin1 (green) and UVRAG (red) in the cortex (e) and hippocampus (f) of Wt and Tg mice (n = 4). Merged images show co-localized Beclin1 and UVRAG in yellow. Scale bar = 30 μm. PI3KC3: Class III phosphatidylinositol 3-kinase; Wt: Wild type; Tg: Transgenic.