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. 2017 Dec 20;130(24):2941–2950. doi: 10.4103/0366-6999.220311

Figure 5.

Figure 5

Alternations of EAL pathway and Rab7-related proteins in 7-month-old APP/PS1 mice. (a) Immunostaining of Rab5, Rab7, LC3B, and Lamp1 in cortex and hippocampus of Wt and Tg mice (n = 4). Scale bar = 50 μm. (b) Double immunofluorescence-labeled Beclin1 (green) and UVRAG (red) in cortex and hippocampus of Wt and Tg mice (n = 4). Scale bar = 40 μm. (c) Representative Western blotting images of EAL markers, UVRAG and Beclin1, in 7-month-old Tg cortex and hippocampus. β-actin as a loading control (n = 4). (d) Quantitative analysis of proteins in Wt and Tg cortex and hippocampus. *P < 0.05, †P < 0.01, ‡P < 0.001. EAL: Endosomal–autophagic–lysosomal; Wt: Wild type; Tg: Transgenic.