Figure 2. Alteration of the microenvironment by soluble epoxide hydrolase inhibition in a unilateral ureteral obstruction (UUO) model.

12-(3-adamantan-1-ylureido)-dodecanoic acid (AUDA) treatment suppressed transforming growth factor (TGF)-β1 and TGF-β2 (A) and increased expression of angiogenic molecules such as von Willebrand factor (vWF), CD31, and VE-cadherin (B). Values are given as mean ± standard error of mean (n = 6 per group for each experiment).

*P < 0.05, **P < 0.01; by ANOVA test.