Table 3.
Uni- and multivariate Cox regression analyses of GNRI change groups for MACCE
| Variable | Unadjusted | *Adjusted | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (yr) | 1.05 (1.02–1.08) | 0.001 | 1.06 (1.02–1.10) | 0.002 |
| Women (vs. men) | 0.89 (0.48–1.63) | 0.70 | 0.80 (0.42–1.52) | 0.50 |
| Diabetes mellitus | 2.25 (1.01–5.01) | 0.04 | 1.04 (0.41–2.49) | 0.9 |
| Cardiovascular disease | 2.21 (1.08–4.54) | 0.03 | 1.67 (0.76–3.66) | 0.21 |
| Ca × P (per mmol2/L2) | 1.03 (0.98–1.03) | 0.78 | 1.02 (0.99–1.05) | 0.10 |
| hs-CRP (per mg/L) | 1.58 (0.80–3.11) | 0.19 | 0.80 (0.45–1.44) | 0.46 |
| Urine volume (L/day) | 0.99 (0.99–1.03) | 0.39 | 1.00 (0.99–1.00) | 0.38 |
| GNRI change groups | ||||
| Improved group | Reference | Reference | ||
| Worsening or stationary group | 2.69 (1.34–5.39) | 0.01 | 2.47 (1.15–5.29) | 0.02 |
*
Adjusted for age, sex, diabetes mellitus, history of cardiovascular disease, Ca × P products, hs-CRP, and residual urine volume.
Improved group included 52 patients with delta GNRI > 0; Worsening or stationary group included 81 patients with delta GNRI ≤ 0.
Ca, calcium; CI, confidence interval; GNRI, geriatric nutritional risk index; HR, hazard ratio; hs-CRP, high-sensitivity C-reactive protein; MACCE, major adverse cardiac and cerebrovascular events; P, phosphorus.