Figure 4.
Increased airway resistance and stiffness in TSG-6–sufficient mice after sHA exposure, due to increases in peripheral tissue values, parallels the ozone-induced changes. Mice received 50 μl of 3 mg/ml sHA by retropharyngeal aspiration, and 2 h later, they were anesthetized, paralyzed, tracheotomized, intubated, and phenotyped for airway physiology measurements via flexiVent. Rrs, respiratory system (whole-lung) resistance; Ers, respiratory system (whole-lung) elastance. Rn, Newtonian (large-airway) resistance. G, damping (peripheral lung resistance). H, peripheral lung elastance. PBS was used as vehicle. Results are represented as means ± S.E. (error bars). The experiment was repeated at least twice. n = 8/group. *, p < 0.05, t test with Holm–Sidak correction for multiple testing.