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. 2017 Nov 9;292(51):20845–20858. doi: 10.1074/jbc.M116.756627

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Figure 8. — TSG-6 rescue of sHA-induced AHR is abolished by ERK or PI3K/Akt inhibition. Isolated tracheal rings were bathed for 30 min in Krebs solution with sHA and added TSG-6 with ERK inhibitor PD98059, PI3K/Akt inhibitor LY294002, or respective vehicles, as indicated, and then assayed for their contractile response to methacholine. A, ERK inhibitor PD98059 abolished the exogenous TSG-6 effect in restoring sHA-induced contractility to methacholine. B, PI3K/Akt inhibitor LY294002 has similar effects. Results are represented as means ± S.E. (error bars). The experiment was repeated at least three times. n = 6–8 tracheal rings/group. *, p < 0.05; **, p < 0.01, TSG-6–deficient with sHA, exogenous TSG-6, and respective inhibitor, compared with TSG-6–deficient with sHA, exogenous TSG-6, and respective vehicle; ANOVA with Tukey's multiple-comparison correction.