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. 2017 Oct 30;292(51):20859–20870. doi: 10.1074/jbc.M117.808022

Scheme 1.

Scheme 1.

Proposed mechanism of CTCF binding to the first exon of hTERT gene for transcriptional regulation. CTCF favors binding hairpin structure, whereas quadruplex formation enhanced by CpG methylation impedes CTCF binding and further leads to gene expression.