Figure 3.

GLUT1 presents additional β-d-Glc binding sites. GLUT1 is oriented as in Fig. 1A. A, β-d-Glc (in red) docking to GLUT1-e2 reveals three potential sites termed peripheral, intermediate, and core. Computed glide scores (GSs) for ligand binding are as follows: peripheral GS = −5.1 kcal/mol, intermediate GS = −5.1 kcal/mol, core GS = −4.9 kcal/mol. B, β-d-Glc (in red) docking to GLUT1-e2o reveals two potential sites termed peripheral and core. Computed GSs for ligand binding are as follows: peripheral GS = −6.0 kcal/mol, core GS = −5.8 kcal/mol. C, β-d-Glc (in red) docking to GLUT1-e1o reveals one potential site with computed GS for ligand binding = −5.1 kcal/mol. D, β-d-Glc (in red) docking to GLUT1-e1. Computed GSs for ligand binding are as follows: core 1 GS = −5.4 kcal/mol.