Figure 1.

Expression of KIBRA, P-YAP, and YAP in human glomerular disease. A and B, immunohistochemistry stainings of serial tissue sections from renal biopsies demonstrate a significantly higher number of KIBRA-positive and P-YAP–positive cells per glomerulus in FSGS cases than in normal kidney tissue, but no significant difference in YAP. The ratio of P-YAP to YAP was significantly increased in FSGS cases. C, representative immunofluorescence images of renal biopsy tissue show colocalization of KIBRA (green) with the podocyte-specific marker synaptopodin (Synpo, red) in FSGS. *, p < 0.05; **, p < 0.005. Scale bars, 50 μm.