Figure 2.

Effects of KIBRA overexpression on Hippo signaling pathway members YAP and LATS. A, representative Western blot showing ectopic overexpression of KIBRA in mouse podocytes. There was significantly greater expression of P-YAP (**) relative to total YAP expression in KIBRA OE podocytes. B, similarly, KIBRA overexpression promoted phosphorylation of LATS with increase in P-LATS/LATS versus control podocytes (*). Expression levels of P-YAP, total YAP, P-LATS, and LATS were normalized to GAPDH expression in all lysate samples. *, p < 0.05; **, p < 0.005. Error bars, S.E.