Figure 3.

Consequences of KIBRA overexpression on YAP-associated gene transcription. Quantitative PCR data reveal significantly decreased mRNA levels for the transcription factors TEAD 1–4 and YAP target Ki-67 in KIBRA OE podocytes versus controls. There were no significant differences between groups in the gene expression levels of YAP itself and other YAP targets. Transcription of synaptopodin was also significantly reduced in the setting of KIBRA overexpression (TEAD, transcriptional enhancer–associated domain; CTGF, connective tissue growth factor; Birc5, baculoviral inhibitor of apoptosis repeat-containing 5, also known as survivin; Synpo, synaptopodin) (*, p < 0.05; **, p < 0.005; N.S., not significant). Error bars, S.E.