Table 1. Model input parameters for Rotarix and their distributions for interval estimation.
| Input parameter | Mean (n or %) |
(SD) or 95% confidence interval | Reference | Probability distribution | |
|---|---|---|---|---|---|
| Benefit: prevented hospitalisation for RVGE before 5 years of age | Annual incidence of RVGE hospitalisations per 1,000 infants | 3.1 | (0.4) | a | Gamma shape = 61.2, scale = 5.09e-5 |
| Number of RVGE deaths per year | 16 | 15–18 | [14] | Lognormal μ = ln(16), σ = 0.046 |
|
| Efficacy after first dose | |||||
| During first 6 months | 96.0% | 90.2%–98.8% | [28] | Beta α = 75.64, β = 3.15 | |
| After 12th month | 90.7% | 85.6%–94.3% | Beta α = 154.4, β = 15.8 | ||
| Efficacy after second dose | |||||
| During first 4 months | 100.0% | 81.8%–100.0% | [28] | Beta α = 1, β = 0.01486 | |
| After 10th month | 92.2% | 65.6%–99.1% | Beta α = 8.16, β = 0.69 | ||
| Risk: vaccine-induced hospitalisation for IS before 1 year of age | Annual incidence of IS hospitalisations per 100,000 infants under 1 year of age | 28.0 | (1.9) | [21] | Gamma shape = 214.4, scale = 1.31e-6 |
| Case–fatality rate of IS | 0.0012 | (0.0007) | [32] | Beta α = 3, β = 2584 | |
| Vaccine-induced RR of IS post dose one during | |||||
| Week 1 | 6.8 | 2.4–19.0 | [9] | Lognormal μ = ln(6.76), σ = 0.52 |
|
| Week 2 and 3 | 3.5 | 1.3– 8.9 | Lognormal μ = ln(3.45), σ = 0.48 |
||
| Vaccine-induced RR of IS post dose two during | |||||
| Week 1 | 2.8 | 1.1– 7.3 | [9] | Lognormal μ = ln(2.84), σ = 0.47 |
|
| Week 2 and 3 | 2.1 | 1.0– 4.6 | Lognormal μ = ln(2.11), σ = 0.39 |
||
IS: intussusception; RR: relative risk; RVGE: rotavirus gastroenteritis; SD: standard deviation.
a EGB (Echantillon Généraliste des Bénéficiaires): extraction of acute gastroenteritis admissions in infant before 5 years of age from the French hospital stays database.