Table 1.
The comparison of clinical data before treatment
| L and Con groups (n =120)
|
M group (n=53)
|
S group (n=67)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| L group
|
Con group
|
p-value | M1 group
|
M2 group
|
p-value | S1 group
|
S2 group
|
p-value | |
| (n=60) | (n=60) | (n=29) | (n=24) | (n=32) | (n=35) | ||||
| SOFA score | 10.77±5.896 | 11.85±5.719 | 0.309 | 5.45±1.502 | 5.58±1.442 | 0.741 | 15.56±3.732 | 16.20±2.837 | 0.432 |
| APACHE II score | 20.35±5.272 | 22.68±7.736 | 0.056 | 16.83±3.496 | 16.04±3.099 | 0.395 | 25.25±4.197 | 27.17±6.883 | 0.177 |
| CPIS score | 8.85±1.793 | 8.53±1.546 | 0.302 | 8.55±1.429 | 8.21±1.318 | 0.368 | 9.19±2.055 | 8.69±1.641 | 0.277 |
| MIC (mg/L) | 11.07±3.922 | 11.47±3.998 | 0.581 | 11.03±3.950 | 11.00±3.956 | 0.975 | 11.25±3.992 | 11.66±4.043 | 0.680 |
| OI (mmHg) | 204.42±34.36 | 198.28±34.03 | 0.328 | 227.7±25.19 | 225.5±24.15 | 0.746 | 182.3±26.31 | 180.2±27.26 | 0.751 |
| PCT (ng/mL) | 6.26±6.950 | 5.98±6.058 | 0.815 | 5.66±5.367 | 5.56±7.856 | 0.957 | 6.21±5.893 | 6.60±6.665 | 0.799 |
| Albumin (g/L) | 26.25±2.972 | 26.10±2.874 | 0.779 | 26.34±2.349 | 27.42±2.083 | 0.088 | 26.16±3.122 | 25.54±3.257 | 0.435 |
| Ccr (mL/min) | 61.40±6.730 | 63.43±7.335 | 0.116 | 66.38±6.758 | 65.29±6.511 | 0.556 | 61.25±7.535 | 60.34±6.183 | 0.591 |
Notes: The Con group (conventional treatment group) received traditional infusion of TZP and the L group (improved administration group) received it as prolonged infusion. Blood drug concentration was detected at different time points. Based on the SOFA cut-off value of 9, the patients were regrouped into M (mild) and S (severe) groups. M1: mild group with prolonged administration; M2: mild group with traditional administration; S1: severe group with prolonged administration; S2: severe group with traditional administration.
Abbreviations: APACHE II, acute physiology and chronic health evaluation II; Ccr, creatinine clearance; CPIS, clinical pulmonary infection score; MIC, minimum inhibitory concentration; OI, oxygenation index; PCT, procalcitonin; SOFA, Sequential Organ Failure Assessment.