Table 3.
The comparison of clinical data in each group after treatment
| L and Con groups (n =120)
|
M group (n=53)
|
S group (n=67)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| L group
|
Con group
|
p-value | M1 group
|
M2 group
|
p-value | S1 group
|
S2 group
|
p-value | |
| (n=60) | (n=60) | (n=29) | (n=24) | (n=32) | (n=35) | ||||
| Antibiotic usage (days) | 11.121±0.772 | 13.227±0.605 | 0.124 | 11.48±3.55 | 10.42±2.569 | 0.225 | 12.94±3.340 | 14.66±3.386 | 0.041 |
| Ventilator time (h) | 145.95±21.46 | 152.01±35.78 | 0.515 | 5.79±4.15 | 6.13±4.28 | 0.956 | 126.09±12.91 | 169.36±16.45 | 0.043 |
| Survival time (days) | 27.77±0.127 | 24.15±1.029 | 0.027 | 28.00±0.00 | 27.17±4.082 | 0.276 | 27.56±1.243 | 21.69±9.048 | 0.001 |
| Clinical efficacy (%) | 88.33 | 86.67 | 0.044 | 96.55 | 96.55 | 0.448 | 78.13 | 57.14 | 0.007 |
| BE (%) | 98.33 | 75.00 | 0.000 | 100.00 | 83.33 | 0.011 | 96.88 | 71.43 | 0.005 |
| 28-day mortality (%) | 1.67 | 8.33 | 0.023 | 0.00 | 0.00 | 1.000 | 3.12 | 14.29 | 0.027 |
Notes: The Con group (conventional treatment group) received traditional infusion of TZP and the L group (improved administration group) received it as prolonged infusion. Blood drug concentration was detected at different time points. Based on the SOFA cut-off value of 9, the patients were regrouped into M (mild) and S (severe) groups. M1: mild group with prolonged administration; M2: mild group with traditional administration; S1: severe group with prolonged administration; S2: severe group with traditional administration.
Abbreviation: BE, bacteriologic efficacy.