Figure 5.

Subcutaneous tumors were isolated 2 weeks after subcutaneous injection of HeLa cells. The expression was normalized to that of GAPDH (n=4). Statistical analysis showed significant differences after stimulation (*P<0.05). The levels of MMP-2 and MMP-9 decreased, and the expression levels of SRC and FAK were upregulated. The migration of HeLa cells was suppressed by the CuS@SiO₂ NPs (80 μg/mL), but it may not be directly associated with SRC and FAK signaling pathway.

Abbreviations: FAK, focal adhesion kinase; MMP, matrix metalloproteinase; NP, nanoparticle.