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. Author manuscript; available in PMC: 2017 Dec 26.
Published in final edited form as: Adv Exp Med Biol. 2017;967:33–45. doi: 10.1007/978-3-319-63245-2_3

Table 3.

Proteins modified by peroxynitrite and involved with pulmonary hypertension

Name Action of Nitration Pathological Function of Nitration Refs
PKG Inhibition Pulmonary vasoconstriction and remodeling (10, 11)
Prostacyclin synthase Inhibition Decreased production of vasodilator prostacyclin and increased production of vasoconstrictors (25, 26)
eNOS Inhibition Induction of eNOS uncoupling generating superoxide and decreasing NO production (11, 55, 59)
Mitochondrial SOD Inhibition Increased oxidative and nitrative stress (30, 31)
ERK Activation Vascular cell proliferation: vascular remodeling (33, 39)
PKC Activation Vascular cell proliferation: vascular remodeling (36, 39)
p85PI3K Inhibition (of PI3K) Endothelial cell apoptosis and endothelial dysfunction (40)
Src kinase Activation Vascular cell proliferation and migration: vascular remodeling (41)

Abbreviations: eNOS, endothelial nitric oxide synthase; ERK, extracellular signal-related kinase; PI3K, phosphoinositide 3 kinase; PK, protein kinase; SOD, superoxide dismutase.