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. Author manuscript; available in PMC: 2018 Oct 21.
Published in final edited form as: Biochem Biophys Res Commun. 2017 Aug 16;492(3):507–512. doi: 10.1016/j.bbrc.2017.08.053

Figure 1. TNF induced vascular permeability in a breast tumor model.

Figure 1

(A) 4T1-GFP tumors growing in the DSFWC of mice were treated with sterile water (control) or TNF 1h prior to administration of fluorescent dextrans in the bloodstream. TNF induces vascular permeability, allowing dextrans to accumulate in the tumor over time. Images show tumors (green) and leaking of fluorescently tagged dextran (red) through tumor vessel walls.(B) Quantified data of fluorescent signal in tumor tissue represented as average ± SEM, n = 3, (#, p<0.05).