Table 3.

History of cancer and the risk of subsequent Alzheimer and non-Alzheimer dementia in a national cohort of male veterans (n=3,429,679)

	Number of cancer cases		Hazard ratio (95% CI)
Cancer type	At baseline	Incident cases	AD dementia (n=82,998)	Non AD dementia (n=285,735)
Any cancer (n=759,984)	316,915	443,069	1.00 (0.97–1.03)	1.17 (1.15–1.19)*
All cancers excluding prostate, colorectal and melanoma (n=346,194)	122,277	223,917	0.89 (0.88–0.90)*	1.21 (1.19–1.24)*
Prostate (n=315,262)	154,405	160,857	1.08 (1.04–1.11)*	1.09 (1.07–1.12)*
Lung (n=83,217)	21,250	61,967	0.79 (0.71–.89)*	1.29 (1.23–1.36)*
Colorectal (n=68,389)	28,811	39,578	0.97 (0.90–1.05)	1.08 (1.04–1.12)*
Bladder (n=48,576)	19,273	29,303	1.01 (0.92–1.11)	1.12 (1.06–1.17)*
Head and neck (n=36,440)	17,898	18,542	0.91 (0.80–1.02)	1.08 (1.02–1.14)*
Melanoma (n=30,139)	11,422	18,717	1.11 (0.99–1.23)	1.12 (1.06–1.18)*
Lymphoma (n= 25,949)	11,329	14,620	0.86 (0.73–0.99)*	1.11 (1.03–1.19)*
Leukemia (n=20,268)	8,262	12,006	0.81 (0.68–0.97)*	1.06 (0.98–1.15)
Renal (n=17,024)	6,008	11,016	0.79 (0.65–0.97)*	1.28 (1.18–1.39)*
Myeloma (n=9,452)	3,572	5,880	0.80 (0.60–1.07)	1.21 (1.07–1.36)*
Esophagus (n=9,123)	2,453	6,670	0.74 (0.52–1.05)	1.14 (0.98–1.32)
Pancreas (n=8,228)	1,501	6,727	0.77 (0.51–1.14)	1.25 (1.06–1.47)*
Liver (n=6,567)	987	5,580	0.76 (0.46–1.23)	1.45 (1.21–1.74)*
Stomach (n=6,111)	1,681	4,430	0.86 (0.62–1.20)	1.40 (1.22–1.61)*
Other (n=75,239)	28,063	47,176	0.99 (0.91–1.07)	1.27 (1.22–1.32)*

^*Statistically significant associations. All analyses adjusted for number of clinic visits in year prior to baseline, follow-up time, cancer treatment, high cholesterol, hypertension, obesity, coronary arterial disease, diabetes, stroke, race. Confidence interval adjusted with Bonferroni correction. HR = Hazard Ratio; CI= confidence interval.