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. Author manuscript; available in PMC: 2018 Sep 7.
Published in final edited form as: Cell. 2017 Sep 7;170(6):1062–1078. doi: 10.1016/j.cell.2017.08.028

Figure 3. p53 alteration spectrum.

Figure 3

(A) The TP53 mutation distribution for 16 cancer types with sufficient available data and frequency of TP53 alteration. Each histogram depicts the number of mutations found at each position along the p53 protein coding sequence, with the transactivation domain (TAD), DNA-binding domain (DBD), and oligomerization domain (OD) illustrated below. Symbol color indicates mutation type, including missense (green), nonsense (red), inframe indels (black), or multiple mutation types (purple). Data source: MSKCC cbio portal (Gao, Schultz, Sci Signal, 2013). (B) Multiple avenues to inactivating the second allele of TP53.