Table III.
miRNA | Malignant vs. benign OGCTsa
|
Malignant OGCTs vs. SCSTsb
|
Benign OGCTs vs. SCSTsb
|
||||||
---|---|---|---|---|---|---|---|---|---|
sRNA seq | RT-qPCR | Concordance | sRNA seq | RT-qPCR | Concordance | sRNA seq | RT-qPCR | Concordance | |
miR-372-3p | Higher | Higher | Yes | Higher | Higher | Yes | Equal | Equal | Yes |
miR-373-3p | Higher | Higher | Yes | Higher | Higher | Yes | Equal | Equal | Yes |
miR-302c-3p | Higher | Higher | Yes | Higher | Higher | Yes | Higher | Equal | No |
miR-199a-5p | Lower | Lower | Yes | Lower | Lower | Yes | Equal | Equal | Yes |
miR-214-5p | Lower | Lower | Yes | Lower | Lower | Yes | Equal | Equal | Yes |
miR-202-3p | Lower | Lower | Yes | Lower | Lower | Yes | Lower | Lower | Yes |
miR-513c-5p | Equal | Lower | No | Lower | Lower | Yes | Lower | Lower | Yes |
let-7f | Lower | Equal | No | Lower | Equal | No | Equal | Equal | Yes |
miR-21 | Equal | Equal | Yes | Higher | Equal | No | Equal | Equal | Yes |
miR-34a | Higher | Equal | No | Higher | Equal | No | Equal | Equal | Yes |
miR-125a-5p | Equal | Equal | Yes | Lower | Equal | No | Equal | Equal | Yes |
miR-193a-3p | Higher | Equal | No | Higher | Equal | No | Higher | Equal | No |
Higher and lower refer to expression in the malignant OGCTs compared to the benign OGCTs.
Higher and lower refer to expression in malignant or benign OGCTs as compared to SCSTs. miRNA, microRNA; OGCT, ovarian germ cell tumor; SCST, sex cord stromal tumor; sRNA seq, small RNA sequencing; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.