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. 2017 Nov 1;52(1):127–138. doi: 10.3892/ijo.2017.4183

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Rg3 represses growth and stemness of colorectal cancer (CRC) cells in vivo. (A) Images of resected LoVo and SW620 orthotopic xenografts. Mice bearing LoVo or SW620 orthotopic xenografts were randomly divided into two groups (five mice in each group): The Rg3 group, which received Rg3 by gastric perfusion daily (25 mg/kg) for 12 consecutive days, and the control group, which was treated with normal saline. (B) Tumor weights of resected LoVo and SW620 orthotopic xenografts. (C–J) Immunohistochemical examination of Ki-67 (C and D), CD24 (E and F), CD44 (G and H) and EpCAM (I and J) levels in LoVo and SW620 orthotopic xenografts. ^*P<0.05 and ^**P<0.01 indicate significant differences compared with the respective control groups.