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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Stem Cells. 2017 Sep 23;35(12):2323–2330. doi: 10.1002/stem.2696

Figure 2. Signaling pathways control the quiescence and activation of hair follicle stem cells.

Figure 2

BMP signaling and FGF18 governs the quiescent cellular state whereas Wnt and FGF7/10 promotes hair growth. Shh produced by transit amplifying cells at the Matrix activates self-renewal of HF-SCs in early Anagen such as Anagen II and III.