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Schematic illustration of targeted MMR-Lobe effects. After intravenous injection, circulating MMR-Lobe specifically binds to plaque macrophages and is taken up by macrophage foam cells. Once inside the plaque macrophages, MMR-Lobe releases lobeglitazone and enhances PPARγ activity, thus resulting in reduction of inflammation activity and enhancement of cholesterol efflux via ABCA1 and ABCG1.
