Severity of skeletal pain and maximum MTC for second donations that were marrow. The severity of maximum skeletal pain (Panel A) and maximum MTC (Panel B) scores measured at baseline, and 2 days, 1 month, 6 months and 1 year post-collection in people who donated marrow once (Marrow only), people whose first and second donations were marrow (Marrow-Marrow) and donors whose first donation was PBSCs and second donation was marrow (PBSC-Marrow). Skeletal pain was defined as pain in at least one of the following sites: back, bone, headache, hip, limb, joint, and neck. The severity of skeletal pain was defined as the maximum grade among these pain sites. MTC was the highest toxicity level of key symptoms including fever in the absence of signs of infection, fatigue, skin rash, local reactions, nausea, vomiting, anorexia, insomnia, dizziness, and syncope.