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(A). Scheme of TPGS-CH=N-DOX prodrug hybrid micelle in “Molecular Economy” way. Left, the P-gp inhibition in MCF-7/ADR cancer cells; Right, the receptor-mediated targeting and anti-metastatic effect in B16F10. (B). Intracellular ATP level depletion effect of TD micelles. (C). Tumor inhibition effect in MCF-7/ADR tumor bearing mice. Reprinted with permission from 23. Copyright 2016 Elsevier.
