Figure 4.

(A). Scheme of FRET-TBH assembly in water and disassembly in 1 mM H₂O₂. (B). The schematic presentation of ROS-triggered and regenerating antitumor nanosystem. A: TBH self-assembling nanosystem (DOX-TBH) and endocytosis mediated by HA through the overexpressed CD44 receptors; B: the breakage of arylboronic linkers by ROS, followed by DOX-TBH rapid disassembly and released DOX and TPGS; C: By acting on mitochondrial respiratory complex II, the released TPGS induced ROS generation for complete disassembly of DOX-TBH; D: TPGS as the inhibitor of P-gp efflux to overcome MDR; E: DOX and ROS induced cell death in nucleus. (C). Scheme of folate-modified redox/pH-sensitive hybrid micelles (PTX@PST-FA) for achieving targeted delivery and overcoming MDR. (D). Antitumor effect against MCF-7/ADR tumor model by hybrid micelles. A and B reprinted with permission from ²⁰. Copyright 2014 Elsevier. C and D reprinted with permission from ¹¹¹. Copyright 2017 Royal Society of Chemistry.