Figure 5.

(A). Fabrication of iRGD mediated PTX and Survivin shRNA co-loaded complex nanoparticles. (B). Design of tLyp-1-conjugated PLA-TPGS nanoparticles as a dual-targeting delivery system for co-delivery of DOX and Ce6. The nanoparticles were internalized by NRP-1 mediated endocytosis and penetrated into the inner areas of the tumor to combat drug resistant cancer via chemo-photodynamic combination therapy. A reprinted with permission from ¹¹². Copyright 2014 American Chemical Society. B reprinted with permission from ¹¹⁴. Copyright 2015 Royal Society of Chemistry.