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. 2018 Jan 1;8(2):464–485. doi: 10.7150/thno.22711

Figure 6.

Figure 6

(A). The tumor inhibition profile of PTX nanoemulsion in MCF-7/ADR tumor. (B). Scheme of the mitochondria-targeted pH-responsive PDPA/TPGS@DOX micelles for overcoming drug resistance in MCF-7/ADR tumor. (a) Cellular uptake; (b) pH-responsive dissociation of micelles in endo/lysosome; (c) the mitochondria targeting effect of TPGS; and (d) nuclear entry of DOX. (C). Schematic representation of mitochondria targeting liposomes. (D). Drug contents in mitochondrial detected by flow cytometry after 4 h incubating A549/cDDP cells. (D1) Blank control; (D2) Free Coumarin; (D3) Coumarin liposomes; (D4) Targeting Coumarin liposomes. (E). Antitumor efficiency in A549/cDDP xenografted tumor. A reprinted with permission from 18. Copyright 2014 Elsevier. B reprinted with permission from 38. Copyright 2015 Elsevier. C, D and E reprinted with permission from 123. Copyright 2013 Elsevier.