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(a) In vivo NIRF images and (b) NIRF intensities of the mice bearing MDA-MB-231 tumor injected with saline, HMSNs@DOX, and HMSNs-S-S-Tf@DOX. (c) Biodistribution of HMSNs-S-S-Tf in major organs and tumor tissue of nude mice at different time of intervals. (n = 6, **p < 0.01)
