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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Clin Immunol. 2017 Nov 24;38(1):77–87. doi: 10.1007/s10875-017-0457-8

Figure 5. WHIM and WHIM-09 neutrophils have increased apoptosis.

Figure 5

Neutrophils were isolated from the indicated subjects and cultured in vitro in RPMI-1640 + 10% FBS + pencillin/streptomycin medium without stimuli at 37°C for 3 hours. A. Representative data. B. Summary data. Data were combined from 2 individual experiments, and summarized as the mean ± SEM. Both WHIM-09 and WHIM-10 were included in both experiments. Three different healthy donors (HDs) were tested: two in one experiment, and one in the second. * p<0.05, two-tailed unpaired parametric t-test. C. PMNs were isolated from the peripheral blood of HDs (n=12), WHIM patients (n=13) and WHIM-09 (collected at 3 different times) and RNAs were isolated for G-CSF receptor mRNA expression. The data were combined from two experiments and mean and SEM were shown. There was no significant difference among the three groups.