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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Lancet Psychiatry. 2017 Nov 28;5(1):51–64. doi: 10.1016/S2215-0366(17)30469-8

Table 3.

Univariate and multivariate moderator analyses.

Univariate Moderator Analyses
Multivariate
Effect Size Analyses
Heterogeneity Analyses
Meta-Regression Analyses
k N b OR 95% CI p I2 p b p R2
Overall Childhood Maltreatment ·67
 Age (Categorical) 17 19,412 <·01
  Adolescent 6 4·44 4·07–4·84 <·0001 1·71% ·41 ·43 ·13
  Adultc 11 2·86 2·16–3·78 <·0001 67·76% <·01
 Age (Continuous) 16 19,282 <·01 ·53
 Percentage Female 18 19,537 <·01 ·62
 Sample Type 17 19,485 ·15
 Childhood Maltreatment Measurea
 NSSI Measure 18 19,537 ·11
 NSSI Timeframe 17 19,343 <·01
  12-Month 4 4·50 4·12–4·90 <·0001 0% ·46 ·15 ·62
  Lifetimec 13 3·06 2·34–3·99 <·0001 70·10% <·0001
Childhood Sexual Abuse
 Age (Categorical) 62 48,121 ·44
 Age (Continuous) 58 46,792 <·01 ·54
 Percentage Female 62 48,246 <·01 ·49
 Sample Type 61 48,150 ·09
 Childhood Maltreatment Measure 61 48,091 ·66
 NSSI Measure 63 48,246 ·10
 NSSI Timeframe 62 48,094 <·01
  12-Month 15 3·52 2·84–4·37 <·0001 67·10% <·01
  Lifetime 47 2·38 2·05–2·76 <·0001 60·48% <·0001
Childhood Physical Abuse
 Age (Categorical) 50 37,696 ·26
 Age (Continuous) 46 36,367 ·02 ·07
 Percentage Female 50 37,821 <·01 ·29
 Sample Type 49 37,683 <·0001
  Clinical 32 1·78 1·56–2·04 <·0001 34·30% ·03
  Community 17 3·29 2·64–4·11 <·0001 78·80% <·0001
 Childhood Maltreatment Measure 48 37,526 ·52
 NSSI Measure 51 37,821 ·13
 NSSI Timeframe 50 37,627 ·14
Childhood Physical Neglect ·68
 Age (Categorical) 25 17,016 ·81
 Age (Continuous) 23 16,686 ·02 ·09
 Percentage Female 26 17,141 <·01 ·28
 Sample Type 24 17,003 <·01
  Clinicalc 13 1·60 1·19–2·15 <·01 55·76% <·01
  Community 11 2·87 2·22–3·71 <·0001 60·77% <·01 ·50 <·01
 Childhood Maltreatment Measure 24 16,986 ·26
 NSSI Measure 26 17,141 ·66
 NSSI Timeframe 26 17,141 <·01
  12-Month 4 3·87 2·59–5·77 <·0001 39·45% ·18 ·61 ·02
  Lifetimec 22 2·01 1·58–2·54 <·0001 67·61% <·0001
Childhood Emotional Abuse ·77
 Age (Categorical) 29 27,768 ·83
 Age (Continuous) 25 26,497 <·01 ·59
 Percentage Female 28 27,768 <·01 ·10
 Sample Type 27 27,630 ·03
  Clinicalc 16 2·69 2·08–3·47 <·0001 75·28% <·0001
  Community 11 3·66 3·31–4·04 <·0001 29·43% ·17 <·01 ·77
 Childhood Maltreatment Measure 29 27,768 <·0001
  Interviewc 4 1·85 1·55–2·21 <·0001 19·88% ·29
  Questionnaire 25 3·32 2·91–3·79 <·0001 60·67% <·0001 ·16 ·44
 NSSI Measure 29 27,768 <·01
  Interviewc 10 2·19 1·64–2·92 <·0001 71·92% <·01
  Questionnaire 19 3·74 3·50–3·99 <·0001 0% ·61 ·56 <·01
 NSSI Timeframe 29 27,768 ·51
Childhood Emotional Neglect
 Age (Categorical) 18 3,343 ·24
 Age (Continuous) 16 3,013 <·01 ·09
 Percentage Female 19 3,468 <·01 ·59
 Sample Type 17 3,330 ·02
  Clinical 12 1·53 1·19–1·97 <·01 67.98% <·01
  Community 5 2·45 1·78–3·36 <·0001 0% .90
 Childhood Maltreatment Measure 19 3,468 ·68
 NSSI Measure 19 3,468 ·82
 NSSI Timeframeb

Note: k = number of unique effects; OR = pooled odds ratio; CI = confidence interval

In analyses of sample type, at-risk and clinical samples were combined and compared to community samples.

a

Not enough observations from studies employing interview measures of childhood maltreatment (k = 2) were available for moderator analysis.

b

All but two studies analyzed lifetime history of NSSI in relation to childhood maltreatment, and thus moderator analysis was not conducted.

c

The category with the smallest effect size in univariate moderator analysis served as the reference group in the corresponding meta-regression analysis.