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Mitochondrial and extra-mitochondrial fatty acid oxidation in NAFLD. Enhanced extra-mitochondrial fatty acid oxidation is associated with the generation of reactive oxygen species (ROS) and it may contribute to hepatic oxidative stress in NAFLD. DCA: dicarboxylic acid, CAC: citric acid cycle, CPT: carnitine palmitoyl transferase, AOX: acyl-CoA oxidase, ETC: electron transfer chain.
