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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2017 Sep 25;24(1):50–54. doi: 10.1016/j.bbmt.2017.09.010

Figure 2.

Figure 2

Histopathology of abdominal skin biopsies demonstrating the effect of anti-ICOS on chronic GVHD of the skin. (A) Skin biopsies from dog H799 collected four days after the third injection of anti-ICOS injection show dense lymphocytic infiltration surrounding the pilo-sebaceous structure and follicular epithelium (arrows). Lymphocytes are present in the superficial and deep dermis and exocytosis of the epidermis is multifocal. (B) The biopsy collected seven days after the third injection of anti-ICOS reveals minimal numbers of lymphocytes surrounding the pilo-sebaceous structures, few lymphocytes in the superficial dermis, and no epidermal exocytosis is present. Magnification is 100×.