Table 1.
Effect of Anti-ICOS on GVHD
| Diagnosis of chronic GVHD | Recurrence of GVHD | Chronic GVHD | |||||
|---|---|---|---|---|---|---|---|
| Dog | Day† | Organ | Response to 1st anti-ICOS | Day† | Clinical Pathol | Day Euthanized | Organ Involvement |
| Anti-ICOS-treated | |||||||
| H789 | 86* | SK, SC | No | NA | N.A. | 98 | SK, LV, LU, ES,PA,CN |
| H799 | 88* | SK,SC | complete | 193 * | SK, SC | 212 | SK, SC, ES, LU, GI, HR |
| H800 | 47* | GI | complete | 87 * | SK, AP | 136 | SK, SG, LU, LV, ES, LG |
| H803 | 112* | SK, SC | complete | 148 | SK | 175 | SK, ES, GI |
| H805 | 111* | GV | complete | 125 | SK, SC | 150 | SK, ES, LV, SG, LG |
| Controls‡ | Clinical Diagnosis | End of Study Histopathology | |||||
| H642 | 66 | SK, GV | NA | NA | NA | 74 | SK, LV, LU, ES |
| H634 | 88 | GV, CN | NA | NA | NA | 103 | SK, SG, LV |
| H678 | 81 | SK, CN | NA | NA | NA | 91 | SK, LV, LU, GI |
| H694 | NA | SK | NA | NA | NA | 106 | SK, SG, LV, LU, LG |
| H708 | 98 | SK, CN | NA | NA | NA | 101 | SK, SG, LV, LU, ES, GI |
| H720 | 43 | SK | NA | NA | NA | 55 | SK, SG, LV, LU, LG |
| H709 | 164 | SK | NA | NA | NA | 189 | SK, SG, LU, LG, ES |
| H698 | 114 | SK, CN | NA | NA | NA | 121 | SK, SG, LV, LU, ES, GI |
Abbreviations: AP = alopecia; CN = conjunctiva; ES = esophagus; GI = gastrointestinal; GV = gingiva; HR = Heart; LG = lacrimal gland; LV= liver; LU = lung; SC = sclera of eyes; SG = salivary gland; SK = Skin; PA = pancreas;
*
Start of anti-ICOS mAb infusion.
†
Days from HCT
‡
Control group [1].