Table 2.

Synopsis of systemic toxicity and inflammation after different treatments for peritoneal carcinomatosis

	Toxicity Renal	Hepatic	Hematologic	Other	Inflammatory Reaction	Drug Concentration
Systemic chemo	Creatinin increase:5-10%*	AST/ALT increase: 36-54%*	Neutropenia: 42% 40 Thrombopenia: 3-4% 41 (III-IV)	Neurotoxicity up to 90% 42 (dose-dependent)	Fever 25% 40	Oxaliplatin: 85 mg/m2
HIPEC	Creatinin increase: 18% 43 Nephro-toxicity: 6% 43 (III-V)*	Hepato-toxicity** 36% (III) 50% (II) 44	Neutropenia: 27% 45 ** 40% 46 ***	Surgical morbidity: 34% (III+IV) 4% mortality 5	CRP at 48h: 180mg/L 47	*Cisplatin 75 mg/m2 +/-Mitomycin-C 10 mg/m2 **Oxaliplatin 460 mg/m2 ***Mitomycin-C 0.8 mg/kg
IP catheter	Nephro-toxicity 7% 32 (III-IV)	Hepato-toxicity 3% 32 (III-IV)	Leukopenia: 40-76% 32, 33 Thrombopenia: 8-12% 32, 33 Anemia: 26% 33	Neurologic events: 19% 32 (III-IV)	Infection: 16% 32 (III-IV)	Cisplatin 100 mg/m2 +/- Paclitaxel 60 mg/m2
PIPAC	None	TransitorygGT increase 36 AST/ALT increase: 14-16%	None	Surgical morbidity: 9% (mainly I+II) 8	CRP at 48h: 45mg/L* CRP at 48h 15mg/L**	*Oxaliplatin 92 mg/m2 **Cisplatin 7.5 mg/m2 + Doxorubicin 1.5 mg/m2

Chemo - chemotherapy, HIPEC - Hyperthermic Intraperitoneal Chemotherapy, IP - intraperitoneal, PIPAC - Pressurized Intraperitoneal Aerosol Chemotherapy, AST - aspartate aminotransferase, ALT - alanine aminotransferase, CRP - C-Reactive Protein, gGT - gamma Glutamyltransferase Severity grades of complications are displayed in brackets.