Figure 6.

Summary drawing on mEHT induced anti-tumor damage mechanisms. Upper panel. Heat stress at 42^oC and direct effect of electric field on dipole molecules both in the extracellular matrix (ECM) and the tumor cell membrane induce caspase-dependent apoptosis resulting in DNA fragmentation. The concomitant release of DAMP signals (Hsp70, calreticulin and HMGB1) support the maturation of antigen presenting cells (APC), which activate cytotoxic T-cells for mediating a secondary, immunogenic cell death (ICD) response. Systemic mEHT effect is possibly facilitated by MTE promoted T-cell migration/activation. Lower panel sums up semiquantitatively how mEHT induced pathways, tumor destruction effect and cell cycle arrest are manifested after using different treatment modules.