Table 1.

MiRNAs dysregulation with targets in CCA

Expression	miRNA	Disease	Target	Function	Reference
Up	miR-21	CCA, ICC	1*	2*	10 23-26 28-29 38 48 51-53
	miR-221	EHCC	PTEN	invasion, migration, EMT	41
	miR-25	CCA	DR4		54
	miR-26a	CCA	3*	proliferation, EMT	55 67 68
	miR-31	ICC	RASA1	proliferation, apoptosis	49
	miR-106a	CCA		migration	56
	miR-141	ICC	CLOCK	proliferation, physiological rhythm	10
	miR-200b	CCA	PI3k, PTEN	multidrug resistance	10
	miR-210	CCA	Mnt	proliferation	57
	miR-199a-3p	CCA	mTOR	multidrug resistance	46
	miR-421	CCA	FXR	proliferation, migration	20
	miR-130a-3p	CCA	PPARG	gemcitabine resistance	47
	Let-7a	CCA	NF2	cell survival, mitogenic, multidrug resistance	33
Down	miR-205	CCA	MMP-2	multidrug resistance	44
	miR-221	CCA	PIK3R1	multidrug resistance	44
	miR-29b	CCA	4*	apoptosis, multidrug resistance	11 14 44 51
	miR-34a	CCA	Per1, Smad4	proliferation, invasion, migration, cell cycle	43 58
	miRNA-101	CCA	VEGF, COX-2	vascular density, growth	37
	miR-124	ICC	SMYD3	invasion, migration	59
	miR-138	CCA	RhoC	proliferation, migration, cell cycle	17
	miR-144	CCA	LIS1	proliferation, invasion, migration	60
	miR-148a	CCA	DNMT-1	proliferation	61
	miR-200b/c	CCA	SUZ12, ROCK2	invasion, migration, multidrug resistance	45
	miR-204	ICC	Slug, Bcl-2	EMT, invasion, migration, apoptosis	30 62
	miR-214	ICC	Twist	EMT, migration	63
	miR-320	ICC	Mcl-1/Bcl-2	apoptosis	64
	miR-370	CCA	MAP3K8	proliferation	34 35
	miR-373	HCCA	MBD2	epigenetic	65
	miR-376c	ICC	GRB2	proliferation, migration	66
	miR-494	CCA	5*	proliferation, cell cycle	15 16
	miR-410	CCA	XIAP	proliferation	50
	miR-141	CCA		proliferation	10
	miR-200c	ICC	NCAM1	EMT	27
	miR-24	CCA	MEN1		21
	Let-7a/miR-99a/miR-125b	CCA	IL-6, IL-6R, IGF1R	invasion, migration	36

1* PI3k, PDCD4, TIMP3, RECK, TPM1, 15-PGDH, PTPN14, PTEN and KLF4

2* proliferation, invasion, migration, apoptosis, EMT and multidrug resistance

3* GSK-3b, TGFβ1 and KRT19

4* Mcl-1, MMP-2c-Myc, Hedgehog, NF-kappaB and PIK3R1

5* CDK6, CDK4, CCND1, CCNE2 and HDAC1