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. 2018 Jan 1;9(1):108–116. doi: 10.7150/jca.21925

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A proposed model for nEGFR target gene transactivation. Upon EGF stimulation, EGFR translocates into the nucleus and binds to chromatin potentially via the AT-rich minimal consensus sequences. In association with RNAPII, Integrator, and Super Elongation Complex, nEGFR functions to activate signaling amplifiers (e.g. FOS, JUN, and EGR1), signaling attenuators (e.g. JUNB and FOSL1) and negative feedback DUSPs (e.g. DUSP1, DUSP2, and DUSP5) for dictating the phenotypic response and cellular transformation.